Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis

BACKGROUND: The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribine, and mitoxantrone, across cell membranes and organelles....

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Dades bibliogràfiques
Publicat a:J Neuroinflammation
Autors principals: Thiele née Schrewe, Lisa, Guse, Kirsten, Tietz, Silvia, Remlinger, Jana, Demir, Seray, Pedreiturria, Xiomara, Hoepner, Robert, Salmen, Anke, Pistor, Maximilian, Turner, Timothy, Engelhardt, Britta, Hermann, Dirk M., Lühder, Fred, Wiese, Stefan, Chan, Andrew
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951012/
https://ncbi.nlm.nih.gov/pubmed/31915017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1677-z
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