Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis

BACKGROUND: The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribine, and mitoxantrone, across cell membranes and organelles....

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Principais autores: Thiele née Schrewe, Lisa, Guse, Kirsten, Tietz, Silvia, Remlinger, Jana, Demir, Seray, Pedreiturria, Xiomara, Hoepner, Robert, Salmen, Anke, Pistor, Maximilian, Turner, Timothy, Engelhardt, Britta, Hermann, Dirk M., Lühder, Fred, Wiese, Stefan, Chan, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951012/
https://ncbi.nlm.nih.gov/pubmed/31915017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1677-z
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