1,25-OH(2) vitamin D(3) and AKT-inhibition increase glucocorticoid induced apoptosis in a model of T-cell acute lymphoblastic leukemia (ALL)

In acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid resistant T-ALL cells. Compared to methylpredniso...

Full description

Saved in:
Bibliographic Details
Published in:Leuk Res Rep
Main Authors: Pistor, Maximilian, Schrewe, Lisa, Haupeltshofer, Steffen, Miclea, Andrei, Faissner, Simon, Chan, Andrew, Hoepner, Robert
Format: Artigo
Language:Inglês
Published: Elsevier 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993358/
https://ncbi.nlm.nih.gov/pubmed/29892547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2018.01.003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items