Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis

The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying this VD/GC interaction. In vitro, GC receptor (GR) expression...

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Publicat a:Acta Neuropathol
Autors principals: Hoepner, Robert, Bagnoud, Maud, Pistor, Maximilian, Salmen, Anke, Briner, Myriam, Synn, Helen, Schrewe, Lisa, Guse, Kirsten, Ahmadi, Farhad, Demir, Seray, Laverick, Louis, Gresle, Melissa, Worley, Paul, Reichardt, Holger Michael, Butzkueven, Helmut, Gold, Ralf, Metz, Imke, Lühder, Fred, Chan, Andrew
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2019
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689294/
https://ncbi.nlm.nih.gov/pubmed/31030237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02018-8
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