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Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of siRNA Duplexes
In this study, we explore the effect of a library of 2′-, 4′-, and 2′,4′-modified uridine nucleosides and their impact on silencing firefly luciferase and on down-regulated in renal cell carcinoma (DRR) gene targets. The modifications studied were 2′-F-ribose, 2′-F-arabinose, 2′-OMe-ribose, 2′-F,4′-...
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| Publicado no: | Nucleic Acid Ther |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc., publishers
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6686699/ https://ncbi.nlm.nih.gov/pubmed/31084536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0792 |
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