Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells

Glioblastoma stem cells (GSCs) are invasive, treatment-resistant brain cancer cells that express downregulated in renal cell carcinoma (DRR), also called FAM107A, a genetic driver of GSC invasion. We developed antibody-antisense oligonucleotide (AON) conjugates to target and reduce DRR/FAM107A expre...

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Gepubliceerd in:Mol Ther Nucleic Acids
Hoofdauteurs: Arnold, Amy E., Malek-Adamian, Elise, Le, Phuong U., Meng, Anika, Martínez-Montero, Saúl, Petrecca, Kevin, Damha, Masad J., Shoichet, Molly S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992475/
https://ncbi.nlm.nih.gov/pubmed/29858087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.04.004
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