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Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol
We developed an efficient system for delivering short interfering RNA (siRNA) to the liver by using α-tocopherol conjugation. The α-tocopherol–conjugated siRNA was effective and safe for RNA interference–mediated gene silencing in vivo. In contrast, when the 13-mer LNA (locked nucleic acid)-DNA gapm...
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| 出版年: | Mol Ther Nucleic Acids |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4345304/ https://ncbi.nlm.nih.gov/pubmed/25584900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.72 |
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