Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol

We developed an efficient system for delivering short interfering RNA (siRNA) to the liver by using α-tocopherol conjugation. The α-tocopherol–conjugated siRNA was effective and safe for RNA interference–mediated gene silencing in vivo. In contrast, when the 13-mer LNA (locked nucleic acid)-DNA gapm...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Nishina, Tomoko, Numata, Junna, Nishina, Kazutaka, Yoshida-Tanaka, Kie, Nitta, Keiko, Piao, Wenying, Iwata, Rintaro, Ito, Shingo, Kuwahara, Hiroya, Wada, Takeshi, Mizusawa, Hidehiro, Yokota, Takanori
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345304/
https://ncbi.nlm.nih.gov/pubmed/25584900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.72
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