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Highly efficient silencing of microRNA by heteroduplex oligonucleotides
AntimiR is an antisense oligonucleotide that has been developed to silence microRNA (miRNA) for the treatment of intractable diseases. Enhancement of its in vivo efficacy and improvement of its toxicity are highly desirable but remain challenging. We here design heteroduplex oligonucleotide (HDO)-an...
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| 發表在: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6698647/ https://ncbi.nlm.nih.gov/pubmed/31214713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz492 |
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