Highly efficient silencing of microRNA by heteroduplex oligonucleotides

AntimiR is an antisense oligonucleotide that has been developed to silence microRNA (miRNA) for the treatment of intractable diseases. Enhancement of its in vivo efficacy and improvement of its toxicity are highly desirable but remain challenging. We here design heteroduplex oligonucleotide (HDO)-an...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nucleic Acids Res
Main Authors: Yoshioka, Kotaro, Kunieda, Taiki, Asami, Yutaro, Guo, Huijia, Miyata, Haruka, Yoshida-Tanaka, Kie, Sujino, Yumiko, Piao, Wenying, Kuwahara, Hiroya, Nishina, Kazutaka, Hara, Rintaro Iwata, Nagata, Tetsuya, Wada, Takeshi, Obika, Satoshi, Yokota, Takanori
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2019
נושאים:
Gene regulation, Chromatin and Epigenetics
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698647/
https://ncbi.nlm.nih.gov/pubmed/31214713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz492
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