Highly efficient silencing of microRNA by heteroduplex oligonucleotides

AntimiR is an antisense oligonucleotide that has been developed to silence microRNA (miRNA) for the treatment of intractable diseases. Enhancement of its in vivo efficacy and improvement of its toxicity are highly desirable but remain challenging. We here design heteroduplex oligonucleotide (HDO)-an...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Yoshioka, Kotaro, Kunieda, Taiki, Asami, Yutaro, Guo, Huijia, Miyata, Haruka, Yoshida-Tanaka, Kie, Sujino, Yumiko, Piao, Wenying, Kuwahara, Hiroya, Nishina, Kazutaka, Hara, Rintaro Iwata, Nagata, Tetsuya, Wada, Takeshi, Obika, Satoshi, Yokota, Takanori
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Gene regulation, Chromatin and Epigenetics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698647/
https://ncbi.nlm.nih.gov/pubmed/31214713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz492
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