Highly efficient silencing of microRNA by heteroduplex oligonucleotides

AntimiR is an antisense oligonucleotide that has been developed to silence microRNA (miRNA) for the treatment of intractable diseases. Enhancement of its in vivo efficacy and improvement of its toxicity are highly desirable but remain challenging. We here design heteroduplex oligonucleotide (HDO)-an...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Yoshioka, Kotaro, Kunieda, Taiki, Asami, Yutaro, Guo, Huijia, Miyata, Haruka, Yoshida-Tanaka, Kie, Sujino, Yumiko, Piao, Wenying, Kuwahara, Hiroya, Nishina, Kazutaka, Hara, Rintaro Iwata, Nagata, Tetsuya, Wada, Takeshi, Obika, Satoshi, Yokota, Takanori
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
Gene regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698647/
https://ncbi.nlm.nih.gov/pubmed/31214713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz492
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