Highly efficient silencing of microRNA by heteroduplex oligonucleotides

AntimiR is an antisense oligonucleotide that has been developed to silence microRNA (miRNA) for the treatment of intractable diseases. Enhancement of its in vivo efficacy and improvement of its toxicity are highly desirable but remain challenging. We here design heteroduplex oligonucleotide (HDO)-an...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Yoshioka, Kotaro, Kunieda, Taiki, Asami, Yutaro, Guo, Huijia, Miyata, Haruka, Yoshida-Tanaka, Kie, Sujino, Yumiko, Piao, Wenying, Kuwahara, Hiroya, Nishina, Kazutaka, Hara, Rintaro Iwata, Nagata, Tetsuya, Wada, Takeshi, Obika, Satoshi, Yokota, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698647/
https://ncbi.nlm.nih.gov/pubmed/31214713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz492
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