DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

Antisense oligonucleotides (ASOs) are recognized therapeutic agents for the modulation of specific genes at the post-transcriptional level. Similar to any medical drugs, there are opportunities to improve their efficacy and safety. Here we develop a short DNA/RNA heteroduplex oligonucleotide (HDO) w...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Nishina, Kazutaka, Piao, Wenying, Yoshida-Tanaka, Kie, Sujino, Yumiko, Nishina, Tomoko, Yamamoto, Tsuyoshi, Nitta, Keiko, Yoshioka, Kotaro, Kuwahara, Hiroya, Yasuhara, Hidenori, Baba, Takeshi, Ono, Fumiko, Miyata, Kanjiro, Miyake, Koichi, Seth, Punit P., Low, Audrey, Yoshida, Masayuki, Bennett, C. Frank, Kataoka, Kazunori, Mizusawa, Hidehiro, Obika, Satoshi, Yokota, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918363/
https://ncbi.nlm.nih.gov/pubmed/26258894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8969
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