Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route

An efficient targeting delivery technology is needed for functional oligonucleotides to exert their potential effect on the target gene without an adverse effect in vivo. Development of enteral delivery systems for nucleic acids is a major challenge because of their large molecular size and instabil...

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Vydáno v:Sci Rep
Hlavní autoři: Murakami, Masahiro, Nishina, Kazutaka, Watanabe, Chie, Yoshida-Tanaka, Kie, Piao, Wenying, Kuwahara, Hiroya, Horikiri, Yuji, Miyata, Kanjiro, Nishiyama, Nobuhiro, Kataoka, Kazunori, Yoshida, Masayuki, Mizusawa, Hidehiro, Yokota, Takanori
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655470/
https://ncbi.nlm.nih.gov/pubmed/26593819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17035
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