Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route

An efficient targeting delivery technology is needed for functional oligonucleotides to exert their potential effect on the target gene without an adverse effect in vivo. Development of enteral delivery systems for nucleic acids is a major challenge because of their large molecular size and instabil...

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Published in:Sci Rep
Main Authors: Murakami, Masahiro, Nishina, Kazutaka, Watanabe, Chie, Yoshida-Tanaka, Kie, Piao, Wenying, Kuwahara, Hiroya, Horikiri, Yuji, Miyata, Kanjiro, Nishiyama, Nobuhiro, Kataoka, Kazunori, Yoshida, Masayuki, Mizusawa, Hidehiro, Yokota, Takanori
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655470/
https://ncbi.nlm.nih.gov/pubmed/26593819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17035
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