Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment

Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 conjugates for obesity treatment. ASOs primarily target fat and liver with poor pene...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cao, Yang, Matsubara, Tomoko, Zhao, Can, Gao, Wei, Peng, Linxiu, Shan, Jinjun, Liu, Zhengxia, Yuan, Fang, Tang, Lingyi, Li, Peixin, Guan, Zhibin, Fang, Zhuyuan, Lu, Xiang, Huang, Hu, Yang, Qin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571112/
https://ncbi.nlm.nih.gov/pubmed/28839185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09598-z
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