A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery

A novel antisense oligonucleotide (ASO) carrier, polyethylenimine conjugated to linoleic acid (PEI-LA), was synthesized and evaluated for delivery of LOR-2501 to tumor cells. LOR-2501 is an ASO targeting ribonucleotide reductase R1 subunit (RRM1). In this study, PEI-LA was synthesized by reacting PE...

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Main Authors: Xie, Jing, Teng, Lesheng, Yang, Zhaogang, Zhou, Chenguang, Liu, Yang, Yung, Bryant C., Lee, Robert J.
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683435/
https://ncbi.nlm.nih.gov/pubmed/23862153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/710502
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