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A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery
A novel antisense oligonucleotide (ASO) carrier, polyethylenimine conjugated to linoleic acid (PEI-LA), was synthesized and evaluated for delivery of LOR-2501 to tumor cells. LOR-2501 is an ASO targeting ribonucleotide reductase R1 subunit (RRM1). In this study, PEI-LA was synthesized by reacting PE...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Hindawi Publishing Corporation
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683435/ https://ncbi.nlm.nih.gov/pubmed/23862153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/710502 |
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