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Attenuated diphtheria toxin mediates siRNA delivery

Toxins efficiently deliver cargo to cells by binding to cell surface ligands, initiating endocytosis, and escaping the endolysosomal pathway into the cytoplasm. We took advantage of this delivery pathway by conjugating an attenuated diphtheria toxin to siRNA, thereby achieving gene downregulation in...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Arnold, Amy E., Smith, Laura J., Beilhartz, Greg L., Bahlmann, Laura C., Jameson, Emma, Melnyk, Roman A., Shoichet, Molly S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195190/
https://ncbi.nlm.nih.gov/pubmed/32917630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4848
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