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Mapping a Molecular Link between Allosteric Inhibition and Activation of the Glycine Receptor
Cys-loop ligand-gated ion channels mediate rapid neurotransmission throughout the central nervous system. They possess agonist recognition sites and allosteric sites where modulators regulate ion channel function. Using strychnine-sensitive glycine receptors, we identified a scaffold of hydrophobic...
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| Опубликовано в: : | Nat Struct Mol Biol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6685790/ https://ncbi.nlm.nih.gov/pubmed/18806798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1492 |
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