Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

Tumors with mismatch repair deficiency (MMR-d) are characterized by sequence alterations in microsatellites and can accumulate thousands of mutations. This high mutational burden renders tumors immunogenic and sensitive to programmed cell death–1 (PD-1) immune checkpoint inhibitors. Yet, despite the...

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Published in:Science
Main Authors: Mandal, Rajarsi, Samstein, Robert M., Lee, Ken-Wing, Havel, Jonathan J., Wang, Hao, Krishna, Chirag, Sabio, Erich Y., Makarov, Vladimir, Kuo, Fengshen, Blecua, Pedro, Ramaswamy, Apoorva T., Durham, Jennifer N., Bartlett, Bjarne, Ma, Xiaoxiao, Srivastava, Raghvendra, Middha, Sumit, Zehir, Ahmet, Hechtman, Jaclyn F., Morris, Luc GT, Weinhold, Nils, Riaz, Nadeem, Le, Dung T., Diaz, Luis A., Chan, Timothy A.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685207/
https://ncbi.nlm.nih.gov/pubmed/31048490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau0447
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