Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Anti-tumor immunity is driven by self vs. non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that can mediate responses to immuno...

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Publicado no:Nat Med
Main Authors: Yang, Wei, Lee, Ken-Wing, Srivastava, Raghvendra M., Kuo, Fengshen, Krishna, Chirag, Chowell, Diego, Makarov, Vladimir, Hoen, Douglas, Dalin, Martin G., Wexler, Leonard, Ghossein, Ronald, Katabi, Nora, Nadeem, Zaineb, Cohen, Marc A., Tian, S. Ken, Robine, Nicolas, Arora, Kanika, Geiger, Heather, Agius, Phaedra, Bouvier, Nancy, Huberman, Kety, Vanness, Katelynd, Havel, Jonathan J., Sims, Jennifer S., Samstein, Robert M., Mandal, Rajarsi, Tepe, Justin, Ganly, Ian, Ho, Alan L., Riaz, Nadeem, Wong, Richard J., Shukla, Neerav, Chan, Timothy A., Morris, Luc G.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558662/
https://ncbi.nlm.nih.gov/pubmed/31011208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0434-2
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