Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Anti-tumor immunity is driven by self vs. non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunogenic neoantigens that can mediate responses to immuno...

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Bibliografske podrobnosti
izdano v:Nat Med
Main Authors: Yang, Wei, Lee, Ken-Wing, Srivastava, Raghvendra M., Kuo, Fengshen, Krishna, Chirag, Chowell, Diego, Makarov, Vladimir, Hoen, Douglas, Dalin, Martin G., Wexler, Leonard, Ghossein, Ronald, Katabi, Nora, Nadeem, Zaineb, Cohen, Marc A., Tian, S. Ken, Robine, Nicolas, Arora, Kanika, Geiger, Heather, Agius, Phaedra, Bouvier, Nancy, Huberman, Kety, Vanness, Katelynd, Havel, Jonathan J., Sims, Jennifer S., Samstein, Robert M., Mandal, Rajarsi, Tepe, Justin, Ganly, Ian, Ho, Alan L., Riaz, Nadeem, Wong, Richard J., Shukla, Neerav, Chan, Timothy A., Morris, Luc G.T.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558662/
https://ncbi.nlm.nih.gov/pubmed/31011208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0434-2
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