Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

Tumors with mismatch repair deficiency (MMR-d) are characterized by sequence alterations in microsatellites and can accumulate thousands of mutations. This high mutational burden renders tumors immunogenic and sensitive to programmed cell death–1 (PD-1) immune checkpoint inhibitors. Yet, despite the...

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Publicado no:Science
Main Authors: Mandal, Rajarsi, Samstein, Robert M., Lee, Ken-Wing, Havel, Jonathan J., Wang, Hao, Krishna, Chirag, Sabio, Erich Y., Makarov, Vladimir, Kuo, Fengshen, Blecua, Pedro, Ramaswamy, Apoorva T., Durham, Jennifer N., Bartlett, Bjarne, Ma, Xiaoxiao, Srivastava, Raghvendra, Middha, Sumit, Zehir, Ahmet, Hechtman, Jaclyn F., Morris, Luc GT, Weinhold, Nils, Riaz, Nadeem, Le, Dung T., Diaz, Luis A., Chan, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685207/
https://ncbi.nlm.nih.gov/pubmed/31048490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau0447
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