Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

Immune checkpoint blockade (ICB) has improved outcomes for patients with advanced cancer, but the determinants of response remain poorly understood. Here we report differential effects of mutations in the homologous recombination genes BRCA1 and BRCA2 on response to ICB in mouse and human tumors, an...

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Udgivet i:Nat Cancer
Main Authors: Samstein, Robert M., Krishna, Chirag, Ma, Xiaoxiao, Pei, Xin, Lee, Ken-Wing, Makarov, Vladimir, Kuo, Fengshen, Chung, Jonathan, Srivastava, Raghvendra M., Purohit, Tanaya A., Hoen, Douglas R, Mandal, Rajarsi, Setton, Jeremy, Wu, Wei, Shah, Rachna, Qeriqi, Besnik, Chang, Qing, Kendall, Sviatoslav, Braunstein, Lior, Weigelt, Britta, Carrillo Albornoz, Pedro Blecua, Morris, Luc G.T., Mandelker, Diana L, Reis-Filho, Jorge S., de Stanchina, Elisa, Powell, Simon N., Chan, Timothy A., Riaz, Nadeem
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023400/
https://ncbi.nlm.nih.gov/pubmed/33834176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-00139-8
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