Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

Immune checkpoint blockade (ICB) has improved outcomes for patients with advanced cancer, but the determinants of response remain poorly understood. Here we report differential effects of mutations in the homologous recombination genes BRCA1 and BRCA2 on response to ICB in mouse and human tumors, an...

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Pubblicato in:Nat Cancer
Autori principali: Samstein, Robert M., Krishna, Chirag, Ma, Xiaoxiao, Pei, Xin, Lee, Ken-Wing, Makarov, Vladimir, Kuo, Fengshen, Chung, Jonathan, Srivastava, Raghvendra M., Purohit, Tanaya A., Hoen, Douglas R, Mandal, Rajarsi, Setton, Jeremy, Wu, Wei, Shah, Rachna, Qeriqi, Besnik, Chang, Qing, Kendall, Sviatoslav, Braunstein, Lior, Weigelt, Britta, Carrillo Albornoz, Pedro Blecua, Morris, Luc G.T., Mandelker, Diana L, Reis-Filho, Jorge S., de Stanchina, Elisa, Powell, Simon N., Chan, Timothy A., Riaz, Nadeem
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8023400/
https://ncbi.nlm.nih.gov/pubmed/33834176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-00139-8
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