Hepatic glutamine synthetase augmentation enhances ammonia detoxification.

The urea cycle and glutamine synthetase (GS) are the two main pathways for waste nitrogen removal and their deficiency results in hyperammonemia. Here, we investigated the efficacy of liver-specific GS overexpression for therapy of hyperammonemia. To achieve hepatic GS overexpression, we generated a...

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Bibliographic Details
Published in:J Inherit Metab Dis
Main Authors: Soria, Leandro R., Nitzahn, Matthew, Angelis, Angela De, Khoja, Suhail, Attanasio, Sergio, Annunziata, Patrizia, Palmer, Donna J., Ng, Philip, Lipshutz, Gerald S., Brunetti-Pierri, Nicola
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684872/
https://ncbi.nlm.nih.gov/pubmed/30724386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jimd.12070
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