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Hepatic glutamine synthetase augmentation enhances ammonia detoxification.
The urea cycle and glutamine synthetase (GS) are the two main pathways for waste nitrogen removal and their deficiency results in hyperammonemia. Here, we investigated the efficacy of liver-specific GS overexpression for therapy of hyperammonemia. To achieve hepatic GS overexpression, we generated a...
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| Publicado no: | J Inherit Metab Dis |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6684872/ https://ncbi.nlm.nih.gov/pubmed/30724386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jimd.12070 |
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