Mathematical Modeling of the Metastatic Colorectal Cancer Microenvironment Defines the Importance of Cytotoxic Lymphocyte Infiltration and Presence of PD-L1 on Antigen Presenting Cells

BACKGROUND: Although immune-based therapy has proven efficacious for some patients with microsatellite instability (MSI) colon cancers, a majority of patients receive limited benefit. Conversely, select patients with microsatellite stable (MSS) tumors respond to checkpoint blockade, necessitating no...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Ann Surg Oncol
Autori principali: Lazarus, Jenny, Oneka, Morgan D., Barua, Souptik, Maj, Tomasz, Lanfranca, Mirna Perusina, Delrosario, Lawrence, Sun, Lei, Smith, J. Joshua, D’Angelica, Michael I., Shia, Jinru, Fang, Jiayun M, Shi, Jiaqi, Di Magliano, Marina Pasca, Zou, Weiping, Rao, Arvind, Frankel, Timothy L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684475/
https://ncbi.nlm.nih.gov/pubmed/31250346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-019-07508-3
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi