Spatial and phenotypic immune profiling of metastatic colon cancer

Paramount to the efficacy of immune checkpoint inhibitors is proper selection of patients with adequate tumor immunogenicity and a robust but suppressed immune infiltrate. In colon cancer, immune-based therapies are approved for patients with DNA mismatch repair (MMR) deficiencies, in whom accumulat...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Lazarus, Jenny, Maj, Tomasz, Smith, J. Joshua, Perusina Lanfranca, Mirna, Rao, Arvind, D’Angelica, Michael I., Delrosario, Lawrence, Girgis, Alexander, Schukow, Casey, Shia, Jinru, Kryczek, Ilona, Shi, Jiaqi, Wasserman, Isaac, Crawford, Howard, Nathan, Hari, Pasca Di Magliano, Marina, Zou, Weiping, Frankel, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302940/
https://ncbi.nlm.nih.gov/pubmed/30429368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121932
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