Spatial and phenotypic immune profiling of metastatic colon cancer

Paramount to the efficacy of immune checkpoint inhibitors is proper selection of patients with adequate tumor immunogenicity and a robust but suppressed immune infiltrate. In colon cancer, immune-based therapies are approved for patients with DNA mismatch repair (MMR) deficiencies, in whom accumulat...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Lazarus, Jenny, Maj, Tomasz, Smith, J. Joshua, Perusina Lanfranca, Mirna, Rao, Arvind, D’Angelica, Michael I., Delrosario, Lawrence, Girgis, Alexander, Schukow, Casey, Shia, Jinru, Kryczek, Ilona, Shi, Jiaqi, Wasserman, Isaac, Crawford, Howard, Nathan, Hari, Pasca Di Magliano, Marina, Zou, Weiping, Frankel, Timothy L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302940/
https://ncbi.nlm.nih.gov/pubmed/30429368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121932
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