Mathematical Modeling of the Metastatic Colorectal Cancer Microenvironment Defines the Importance of Cytotoxic Lymphocyte Infiltration and Presence of PD-L1 on Antigen Presenting Cells

BACKGROUND: Although immune-based therapy has proven efficacious for some patients with microsatellite instability (MSI) colon cancers, a majority of patients receive limited benefit. Conversely, select patients with microsatellite stable (MSS) tumors respond to checkpoint blockade, necessitating no...

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Detalhes bibliográficos
Publicado no:Ann Surg Oncol
Main Authors: Lazarus, Jenny, Oneka, Morgan D., Barua, Souptik, Maj, Tomasz, Lanfranca, Mirna Perusina, Delrosario, Lawrence, Sun, Lei, Smith, J. Joshua, D’Angelica, Michael I., Shia, Jinru, Fang, Jiayun M, Shi, Jiaqi, Di Magliano, Marina Pasca, Zou, Weiping, Rao, Arvind, Frankel, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684475/
https://ncbi.nlm.nih.gov/pubmed/31250346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-019-07508-3
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