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Mathematical Modeling of the Metastatic Colorectal Cancer Microenvironment Defines the Importance of Cytotoxic Lymphocyte Infiltration and Presence of PD-L1 on Antigen Presenting Cells

BACKGROUND: Although immune-based therapy has proven efficacious for some patients with microsatellite instability (MSI) colon cancers, a majority of patients receive limited benefit. Conversely, select patients with microsatellite stable (MSS) tumors respond to checkpoint blockade, necessitating no...

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Detaylı Bibliyografya
Yayımlandı:Ann Surg Oncol
Asıl Yazarlar: Lazarus, Jenny, Oneka, Morgan D., Barua, Souptik, Maj, Tomasz, Lanfranca, Mirna Perusina, Delrosario, Lawrence, Sun, Lei, Smith, J. Joshua, D’Angelica, Michael I., Shia, Jinru, Fang, Jiayun M, Shi, Jiaqi, Di Magliano, Marina Pasca, Zou, Weiping, Rao, Arvind, Frankel, Timothy L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684475/
https://ncbi.nlm.nih.gov/pubmed/31250346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-019-07508-3
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