Mathematical Modeling of the Metastatic Colorectal Cancer Microenvironment Defines the Importance of Cytotoxic Lymphocyte Infiltration and Presence of PD-L1 on Antigen Presenting Cells

BACKGROUND: Although immune-based therapy has proven efficacious for some patients with microsatellite instability (MSI) colon cancers, a majority of patients receive limited benefit. Conversely, select patients with microsatellite stable (MSS) tumors respond to checkpoint blockade, necessitating no...

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Dades bibliogràfiques
Publicat a:Ann Surg Oncol
Autors principals: Lazarus, Jenny, Oneka, Morgan D., Barua, Souptik, Maj, Tomasz, Lanfranca, Mirna Perusina, Delrosario, Lawrence, Sun, Lei, Smith, J. Joshua, D’Angelica, Michael I., Shia, Jinru, Fang, Jiayun M, Shi, Jiaqi, Di Magliano, Marina Pasca, Zou, Weiping, Rao, Arvind, Frankel, Timothy L.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684475/
https://ncbi.nlm.nih.gov/pubmed/31250346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-019-07508-3
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