Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55

Complement activation plays an important role in pharmacokinetic and performance of intravenously administered nanomedicines. Significant efforts have been directed toward engineering of nanosurfaces with low complement activation, but due to promiscuity of complement factors and redundancy of pathw...

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Publicado en:J Control Release
Main Authors: Gifford, Geoffrey, Vu, Vivian P., Banda, Nirmal K., Holers, V Michael, Wang, Guankui, Groman, Ernest, Backos, Donald, Scheinman, Robert, Moghimi, S. Moein, Simberg, Dmitri
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684249/
https://ncbi.nlm.nih.gov/pubmed/30974134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2019.04.009
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