Activation of human complement system by dextran-coated iron oxide nanoparticles is not affected by dextran/Fe ratio, hydroxyl modifications and crosslinking

While having tremendous potential as therapeutic and imaging tools, the clinical use of engineered nanoparticles has been associated with serious safety concerns. Activation of the complement cascade and release of proinflammatory factors C3a and C5a may contribute to infusion-related reactions, whe...

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Bibliographic Details
Main Authors: Guankui Wang, Fangfang Chen, Nirmal Banda, VM Holers, Linping Wu, Moein Moghimi, Dmitri Simberg
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
Complement C3
Complement System Proteins
Properdin
Lectin pathway
Iron oxide nanoparticles
Dextran
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00418/full
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