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Activation of human complement system by dextran-coated iron oxide nanoparticles is not affected by dextran/Fe ratio, hydroxyl modifications and crosslinking

While having tremendous potential as therapeutic and imaging tools, the clinical use of engineered nanoparticles has been associated with serious safety concerns. Activation of the complement cascade and release of proinflammatory factors C3a and C5a may contribute to infusion-related reactions, whe...

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Библиографические подробности
Главные авторы: Guankui Wang, Fangfang Chen, Nirmal Banda, VM Holers, Linping Wu, Moein Moghimi, Dmitri Simberg
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2016-10-01
Серии:Frontiers in Immunology
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Online-ссылка:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00418/full
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