A polymorphism in intron I of the human angiotensinogen gene (hAGT) affects binding by HNF3 and hAGT expression and increases blood pressure in mice

Angiotensinogen (AGT) is the precursor of one of the most potent vasoconstrictors, peptide angiotensin II. Genome-wide association studies have shown that two A/G polymorphisms (rs2493134 and rs2004776), located at +507 and +1164 in intron I of the human AGT (hAGT) gene, are associated with hyperten...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Mopidevi, Brahmaraju, Kaw, Meenakshi K., Sivankutty, Indu, Jain, Sudhir, Perla, Sravan Kumar, Kumar, Ashok
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682742/
https://ncbi.nlm.nih.gov/pubmed/31201268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007715
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