A polymorphism in intron I of the human angiotensinogen gene (hAGT) affects binding by HNF3 and hAGT expression and increases blood pressure in mice

Angiotensinogen (AGT) is the precursor of one of the most potent vasoconstrictors, peptide angiotensin II. Genome-wide association studies have shown that two A/G polymorphisms (rs2493134 and rs2004776), located at +507 and +1164 in intron I of the human AGT (hAGT) gene, are associated with hyperten...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Mopidevi, Brahmaraju, Kaw, Meenakshi K., Sivankutty, Indu, Jain, Sudhir, Perla, Sravan Kumar, Kumar, Ashok
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682742/
https://ncbi.nlm.nih.gov/pubmed/31201268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007715
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