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Transgenic Mice with −6A Haplotype of the Human Angiotensinogen Gene Have Increased Blood Pressure Compared with −6G Haplotype

Hypertension is a serious risk factor for cardiovascular disease, and the angiotensinogen (AGT) gene locus is associated with human essential hypertension. The human AGT (hAGT) gene has an A/G polymorphism at −6, and the −6A allele is associated with increased blood pressure. However, transgenic mic...

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Bibliografische gegevens
Hoofdauteurs: Jain, Sudhir, Tillinger, Andrej, Mopidevi, Brahmaraju, Pandey, Varunkumar G., Chauhan, Chetankumar K., Fiering, Steven N., Warming, Soren, Kumar, Ashok
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003415/
https://ncbi.nlm.nih.gov/pubmed/20978123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167585
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