A Haplotype of Angiotensin Receptor Type 1 Associated with Human Hypertension Increases Blood Pressure in Transgenic Mice

The renin-angiotensin system plays an important role in the regulation of blood pressure via angiotensin II and the angiotensin II receptor type 1 (AT(1)R). Human AT(1)R gene promoter has four SNPs: T/A at −777, T/G at −680, A/C at −214, and A/G at −119, that are in linkage disequilibrium. Variants...

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Hlavní autoři: Jain, Sudhir, Prater, Alicia, Pandey, Varunkumar, Rana, Anita, Puri, Nitin, Kumar, Ashok
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873561/
https://ncbi.nlm.nih.gov/pubmed/24202179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520023
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