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Dexamethasone Promotes Hypertension by Allele-specific Regulation of the Human Angiotensinogen Gene

The human angiotensinogen (hAGT) gene has polymorphisms in its 2.5-kb promoter that form two haplotype (Hap) blocks: −6A/G (−1670A/G, −1562C/T, and −1561T/C) and −217A/G (−532T/C, −793A/G, −1074T/C, and −1178G/A). Hap −6A/−217A is associated with human hypertension, whereas Hap −6G/−217G reduces car...

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Foilsithe in:J Biol Chem
Main Authors: Pandey, Varunkumar G., Jain, Sudhir, Rana, Anita, Puri, Nitin, Arudra, Sri Krishna C., Mopidevi, Brahmaraju, Kaw, Meenakshi, Nasjletti, Alberto, Kumar, Ashok
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342485/
https://ncbi.nlm.nih.gov/pubmed/25568318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.601922
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