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Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress
Familial early-onset forms of Alzheimer's disease (AD) are linked to overproduction of amyloid beta (Aβ) peptides, while decreased clearance of Aβ is the driving force leading to its toxic accumulation in late-onset (sporadic) AD. Oxidative modifications and defective function have been reporte...
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| Gepubliceerd in: | Redox Biol |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Elsevier
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675974/ https://ncbi.nlm.nih.gov/pubmed/31376793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101283 |
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