Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress

Familial early-onset forms of Alzheimer's disease (AD) are linked to overproduction of amyloid beta (Aβ) peptides, while decreased clearance of Aβ is the driving force leading to its toxic accumulation in late-onset (sporadic) AD. Oxidative modifications and defective function have been reporte...

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Pubblicato in:Redox Biol
Autori principali: de Dios, Cristina, Bartolessis, Isabel, Roca-Agujetas, Vicente, Barbero-Camps, Elisabet, Mari, Montserrat, Morales, Albert, Colell, Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675974/
https://ncbi.nlm.nih.gov/pubmed/31376793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101283
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