Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress

Familial early-onset forms of Alzheimer's disease (AD) are linked to overproduction of amyloid beta (Aβ) peptides, while decreased clearance of Aβ is the driving force leading to its toxic accumulation in late-onset (sporadic) AD. Oxidative modifications and defective function have been reporte...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: de Dios, Cristina, Bartolessis, Isabel, Roca-Agujetas, Vicente, Barbero-Camps, Elisabet, Mari, Montserrat, Morales, Albert, Colell, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675974/
https://ncbi.nlm.nih.gov/pubmed/31376793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101283
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