Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease

BACKGROUND: Emerging evidence indicates that impaired mitophagy-mediated clearance of defective mitochondria is a critical event in Alzheimer’s disease (AD) pathogenesis. Amyloid-beta (Aβ) metabolism and the microtubule-associated protein tau have been reported to regulate key components of the mito...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Roca-Agujetas, Vicente, Barbero-Camps, Elisabet, de Dios, Cristina, Podlesniy, Petar, Abadin, Xenia, Morales, Albert, Marí, Montserrat, Trullàs, Ramon, Colell, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941983/
https://ncbi.nlm.nih.gov/pubmed/33685483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00435-6
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