Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress

Familial early-onset forms of Alzheimer's disease (AD) are linked to overproduction of amyloid beta (Aβ) peptides, while decreased clearance of Aβ is the driving force leading to its toxic accumulation in late-onset (sporadic) AD. Oxidative modifications and defective function have been reporte...

Full description

Saved in:
Bibliographic Details
Published in:Redox Biol
Main Authors: de Dios, Cristina, Bartolessis, Isabel, Roca-Agujetas, Vicente, Barbero-Camps, Elisabet, Mari, Montserrat, Morales, Albert, Colell, Anna
Format: Artigo
Language:Inglês
Published: Elsevier 2019
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675974/
https://ncbi.nlm.nih.gov/pubmed/31376793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101283
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items