Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by an RORγt inverse agonist

Airway neutrophilia occurs in approximately 50% of patients with asthma and is associated with particularly severe disease. Unfortunately, this form of asthma is usually refractory to corticosteroid treatment, and there is an unmet need for new therapies. Pulmonary neutrophilic inflammation is assoc...

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Vydáno v:JCI Insight
Hlavní autoři: Whitehead, Gregory S., Kang, Hong Soon, Thomas, Seddon Y., Medvedev, Alexander, Karcz, Tadeusz P., Izumi, Gentaro, Nakano, Keiko, Makarov, Sergei S., Nakano, Hideki, Jetten, Anton M., Cook, Donald N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675583/
https://ncbi.nlm.nih.gov/pubmed/31184998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125528
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