Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by an RORγt inverse agonist

Airway neutrophilia occurs in approximately 50% of patients with asthma and is associated with particularly severe disease. Unfortunately, this form of asthma is usually refractory to corticosteroid treatment, and there is an unmet need for new therapies. Pulmonary neutrophilic inflammation is assoc...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Whitehead, Gregory S., Kang, Hong Soon, Thomas, Seddon Y., Medvedev, Alexander, Karcz, Tadeusz P., Izumi, Gentaro, Nakano, Keiko, Makarov, Sergei S., Nakano, Hideki, Jetten, Anton M., Cook, Donald N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675583/
https://ncbi.nlm.nih.gov/pubmed/31184998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125528
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