Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by an RORγt inverse agonist

Airway neutrophilia occurs in approximately 50% of patients with asthma and is associated with particularly severe disease. Unfortunately, this form of asthma is usually refractory to corticosteroid treatment, and there is an unmet need for new therapies. Pulmonary neutrophilic inflammation is assoc...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Whitehead, Gregory S., Kang, Hong Soon, Thomas, Seddon Y., Medvedev, Alexander, Karcz, Tadeusz P., Izumi, Gentaro, Nakano, Keiko, Makarov, Sergei S., Nakano, Hideki, Jetten, Anton M., Cook, Donald N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675583/
https://ncbi.nlm.nih.gov/pubmed/31184998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125528
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