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Quantifying drug combination synergy along potency and efficacy axes.
Two goals motivate treating diseases with drug combinations: reduce off-target toxicity by minimizing doses (synergistic potency), and improve outcomes by escalating effect (synergistic efficacy). Established drug synergy frameworks obscure such distinction, failing to harness the potential of moder...
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| Publicado no: | Cell Syst |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675406/ https://ncbi.nlm.nih.gov/pubmed/30797775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.01.003 |
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