Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition

Dysregulated metabolism can broadly affect therapy resistance by influencing compensatory signaling and expanding proliferation. Given many BRAF-mutated melanoma patients experience disease progression with targeted BRAF inhibitors, we hypothesized therapeutic response is related to tumor metabolic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hardeman, Keisha N., Peng, Chengwei, Paudel, Bishal B., Meyer, Christian T., Luong, Thong, Tyson, Darren R., Young, Jamey D., Quaranta, Vito, Fessel, Joshua P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311997/
https://ncbi.nlm.nih.gov/pubmed/28205616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42604
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