Drug-Tolerant Idling Melanoma Cells Exhibit Theory-Predicted Metabolic Low-Low Phenotype

Cancer cells adjust their metabolic profiles to evade treatment. Metabolic adaptation is complex and hence better understood by an integrated theoretical-experimental approach. Using a minimal kinetic model, we predicted a previously undescribed Low/Low (L/L) phenotype, characterized by low oxidativ...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Jia, Dongya, Paudel, B. Bishal, Hayford, Corey E., Hardeman, Keisha N., Levine, Herbert, Onuchic, José N., Quaranta, Vito
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457027/
https://ncbi.nlm.nih.gov/pubmed/32923395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01426
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