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Intracranial Adeno-Associated Virus-Mediated Delivery of Anti-Pan Amyloid β, Amyloid β40, and Amyloid β42 Single-Chain Variable Fragments Attenuates Plaque Pathology in Amyloid Precursor Protein Mice

Accumulation of amyloid β protein (Aβ) aggregates is hypothesized to trigger a pathological cascade that causes Alzheimer's disease (AD). Active or passive immunizations targeting Aβ are therefore of great interest as potential therapeutic strategies. We have evaluated the use of recombinant an...

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Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Levites, Yona, Jansen, Karen, Smithson, Lisa A., Dakin, Rachel, Holloway, Vallie M., Das, Pritam, Golde, Todd E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674861/
https://ncbi.nlm.nih.gov/pubmed/17108166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2795-06.2006
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