Anti-Aβ(42)- and anti-Aβ(40)-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

Accumulation and aggregation of amyloid β peptide 1–42 (Aβ(42)) in the brain has been hypothesized as triggering a pathological cascade that causes Alzheimer disease (AD). To determine whether selective targeting of Aβ(42) versus Aβ(40) or total Aβ is an effective way to prevent or treat AD, we comp...

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Main Authors: Levites, Yona, Das, Pritam, Price, Robert W., Rochette, Marjorie J., Kostura, Lisa A., McGowan, Eileen M., Murphy, Michael P., Golde, Todd E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307561/
https://ncbi.nlm.nih.gov/pubmed/16341263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25410
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