Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice

Considerable circumstantial evidence suggests that Aβ42 is the initiating molecule in Alzheimer's disease (AD) pathogenesis. However, the absolute requirement for Aβ42 for amyloid deposition has never been demonstrated in vivo. We have addressed this by developing transgenic models that express...

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Détails bibliographiques
Auteurs principaux: McGowan, Eileen, Pickford, Fiona, Kim, Jungsu, Onstead, Luisa, Eriksen, Jason, Yu, Cindy, Skipper, Lisa, Murphy, M. Paul, Beard, Jenny, Das, Pritam, Jansen, Karen, DeLucia, Michael, Lin, Wen-Lang, Dolios, Georgia, Wang, Rong, Eckman, Christopher B., Dickson, Dennis W., Hutton, Mike, Hardy, John, Golde, Todd
Format: Artigo
Langue:Inglês
Publié: 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1373682/
https://ncbi.nlm.nih.gov/pubmed/16039562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2005.06.030
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