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Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43
TAR DNA binding protein-43 (TDP-43) is the pathologic substrate of neuronal and glial inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTDL-U) and in amyotrophic lateral sclerosis (ALS). Mutations in the progranulin gene (PGRN) have been shown to cause familial FTL...
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| 出版年: | J Neurosci |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Society for Neuroscience
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6673167/ https://ncbi.nlm.nih.gov/pubmed/17898224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3421-07.2007 |
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