Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor

Sortilin 1 regulates the levels of brain progranulin (PGRN), a neurotrophic growth factor that, when deficient, is linked to cases of frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43)–positive inclusions (FTLD-TDP). We identified a specific splicing enhancer element that reg...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Prudencio, Mercedes, Jansen-West, Karen R., Lee, Wing C., Gendron, Tania F., Zhang, Yong-Jie, Xu, Ya-Fei, Gass, Jennifer, Stuani, Cristiana, Stetler, Caroline, Rademakers, Rosa, Dickson, Dennis W., Buratti, Emanuele, Petrucelli, Leonard
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535614/
https://ncbi.nlm.nih.gov/pubmed/23236149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211577110
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars