Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43

TAR DNA binding protein-43 (TDP-43) is the pathologic substrate of neuronal and glial inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTDL-U) and in amyotrophic lateral sclerosis (ALS). Mutations in the progranulin gene (PGRN) have been shown to cause familial FTL...

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Publicado no:J Neurosci
Main Authors: Zhang, Yong-Jie, Xu, Ya-fei, Dickey, Chad A., Buratti, Emanuele, Baralle, Francisco, Bailey, Rachel, Pickering-Brown, Stuart, Dickson, Dennis, Petrucelli, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673167/
https://ncbi.nlm.nih.gov/pubmed/17898224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3421-07.2007
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